Experts Panel

Prof.Patrick Lam, PhD

Blumberg Institute, USA

Dr.Toyonobu Usuki

Sophia University,  Japan

Prof.Dalia Omran

Kasr Al-Ainy Medical School ,Egypt

Prof. Gautam Sethi

National University of Singapore

Prof.A. Jayashree

JNTUH, India

Dr.Gopal Natesan

MAHSA University, Kuala Lumpur

Dr. Siva Reddy Kotla

Anderson Cancer Center, USA

Dr.Parathasarathi Das

IIT – ISM, Dhanbad, India

Dr.Jianhua Luo, MD, PhD

University of Pittsburgh,US

Dr. Rakeshwar Bandichhor

Dr. Reddy’s Laboratories, India

Dr Pawan Saharan

Founder CEO Biomix Network INC. USA

ICCB 2019, Singapore
International Conference on Cancer biology and Anti-Cancer Therapies ICCB 2019, Singapore deals with the study of basic researches in the field of cancer biology, Oncology, and new treatment approaches of anti-cancer therapies. It involves identifying causes and to develop strategies for diagnosis, prevention, treatment and cure for various types of Cancer like breast Cancer, Colorectal Cancer, Lung Cancer and Cervical Cancer, Leukaemia, Bone Marrow, DNA Repair Etc.
ICCB 2019, Singapore is the premier event that brings together a unique and International mix of Academicians, Professional Doctors, Oncology Experts, Young Researchers, and decision makers both from academia and industry across the globe to exchange their knowledge, experience and research innovations in the field of Cancer and Therapeutics. Hoping that events like this one would help setting-up “new grounds for discussion” to placing the science of our young researchers onto the entrepreneurial paths in the long-run.
We look forward to welcoming you to the beautiful city of Singapore in June 2019.

Cancer Biology
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumours, which do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. Cancer biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. Cancer biology represents the application of systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis to develop effective predictive models that can assist scientists and clinicians in the validations of new therapies and drugs.

Preventive oncology
Preventive oncology embraces any measures that may be taken to prevent the development or progression of malignant disease. Preventive oncologic measures include not only traditional public health approaches to prevention-education about the dangers of environmental carcinogens, programs to reduce smoking, education about diet and immunization, and so forth – but also specific therapeutic actions, such as subcutaneous mastectomy in patients at high risk of breast cancer. Public health measures attempt to reduce the incidence of some of the so-called preventable cancers, such as lung, mouth, liver and uterine cervical cancer.

Cancer Immunotherapy and Immunology
With regards to cancer immunity, cancer immunotherapy is actively being pursued to treat a variety of cancers particularly focusing on immune modulation using antibodies that block immune regulatory checkpoints and chimeric antigen receptor (CAR)–modified T cells. Particularly, selectins have been described to contribute to the maintenance of the tumor microenvironment and other lectins such as siglecs also regulate immune responses by binding to cancer cell-derived glycans. However, the potential to target these molecules remain poorly investigated.

Cell Signalling
Cell signaling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Cell signaling can be classified to be mechanical and biochemical based on the type of the signal. Mechanical signals are the forces exerted on the cell and the forces produced by the cell. These forces can both be sensed and responded by the cells. Many cell signals are carried by molecules that are released by one cell and move to make contact with another cell. Endocrine signals are called hormones. Hormones are produced by endocrine cells and they travel through the blood to reach all parts of the body.

Genetic Cancer
Cancer is a common disease, and almost every family has a number of members who suffer from cancer. However, this does not generally mean that families have a hereditary predisposition to cancer. The vast majority of cancer cases originate from the combined effect of hereditary as well as external influences, such as environmental and lifestyle factors. Cancer is not inherited. It is only the genetic defect that can lead to cancer that is inherited, which means that the predisposition to getting cancer, or increased risk, can be inherited. However, this is not common. According to current estimates, only about one in 10 cases of cancer is associated with hereditary predisposition. An inherited genetic defect is not necessarily passed on to all members of the same family, and not everyone who receives the same defective gene will develop cancer. It is also worth remembering that the genetic changes that occur in cancerous tumours are not passed on genetically to one’s offspring.
Breast cancer is the most common form of cancer among women. The best-known genes that carry a high risk of causing breast and ovarian cancer are the BRCA1 and BRCA2 genes. There is also a susceptibility gene, which is linked to a moderate risk of breast cancer. About two-three per cent of the new cases of colorectal cancer detected each year are hereditary. Families in which gene defect causing a predisposition to hereditary non-polyposis colorectal cancer (Lynch Syndrome) has been detected. Cancer cannot be found using gene testing, but with the help of current genetics research we can detect some cancer-predisposing gene defects. At present, there is no simple genetic test for those interested in being tested. Genetic tests are only used when there is clear evidence of a possible hereditary predisposition to cancer.

Cancer Metabolomics
Metabolomics, one of the “omic” sciences in systems biology, is the global assessment and validation of endogenous small-molecule biochemicals (metabolites) within a biologic system. Initially, putative quantitative metabolic biomarkers for cancer detection and/or assessment of efficacy of anticancer treatment are usually discovered in a preclinical setting followed by translational validation of these biomarkers in biofluid or tumor tissue. Based on the tumor origin, various biofluids, such as blood, urine, and expressed prostatic secretions, can be used for validating metabolic biomarkers noninvasively in cancer patients. Metabolite detection and quantification is usually carried out by nuclear magnetic resonance (NMR) spectroscopy, while mass spectrometry (MS) provides another highly sensitive metabolomics technology.

Cancer Biomarkers
One of the best ways to diagnose cancer early, aid in its prognosis, or predict therapeutic response, is to use serum or tissue biomarkers. Cancer biomarkers can be DNA, mRNA, proteins, metabolites, or processes such as apoptosis, angiogenesis or proliferation. The markers are produced either by the tumor itself or by other tissues, in response to the presence of cancer or other associated conditions, such as inflammation. Such biomarkers can be found in a variety of fluids, tissues and cell lines. Definition of biomarker is: “A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.” Naturally, a cancer biomarker pertains to any biomarker that fits the aforementioned definition but only for cancer, and no other disease. An ideal cancer biomarker should be able to be measured easily, reliably and cost-effectively by use of an assay with high analytical sensitivity and specificity. One of the most well-known cancer biomarkers is Prostate-specific antigen, or PSA, and elevated levels of PSA in men tend to signal for prostate cancer. Actually, cancer biomarkers are more than just a signal of the disease, and have many roles in the fight against cancer.

Cancer therapy
Cancer therapy describes the treatment of cancer in a patient, often with surgery, chemotherapy and/or radiotherapy. Targeted therapies are also available for some cancer types. A cancer patient might receive many different types of therapy, including those aimed at relieving the symptoms of cancer, such as pain. Cancer can be treated by surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy (including immunotherapy such as monoclonal antibody therapy) and synthetic lethality. The choice of therapy depends upon the location and grade of the tumor and the stage of the disease, as well as the general state of the patient (performance status). A number of experimental cancer treatments are also under development. Under current estimates, two in five people will have cancer at some point in their lifetime. Complete removal of the cancer without damage to the rest of the body (that is, achieving cure with near-zero adverse effects) is the ideal goal of treatment and is often the goal in practice. Sometimes this can be accomplished by surgery, but the propensity of cancers to invade adjacent tissue or to spread to distant sites by microscopic metastasis often limits its effectiveness; and chemotherapy and radiotherapy can have a negative effect on normal cells.


Advances in Cancer Research
Cancer has likely been around as long as humans have. But over the years, our ability to test for the disease and treat it has greatly improved. More people who get cancer are living longer. Some are being cured. Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. The first ACR volume came out in the year that Watson and Crick reported on the central dogma of biology, the DNA double helix. In the first 100 volumes are found many contributions by some of those who helped shape the revolution and who made many of the remarkable discoveries in cancer research that have developed from it. The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research.

Organ Specific Cancer
Organ Specific Cancer is usually named based on the location of the Cancer cell in the body organ. There are more than 100 types of Cancer and it may occur anywhere in the human body. Breast Cancer is most common in Women, and Prostate cancer is common in Men. Lung cancer and colorectal cancer occurs commonly in both men and women. Cancer also defined by the type of the cell formed them, like epithelial or squamous cell. There are different types of Cancers based on location of cancer in the body organ. These types of Malignancies come under the category of Organ Specific Cancer.
Breast Cancer | Lung Cancer | Prostate Cancer | Ovary Cancer | Non Hodgkin Lymphoma

Drug Resistance
Microbes are living organisms that multiply frequently and spread rapidly. They include bacteria (e.g., Staphylococcus aureus, which causes some staph infections), viruses (e.g., influenza, which causes the flu), fungi (e.g., Candida albicans, which causes some yeast infections), and parasites (e.g., Plasmodium falciparum, which causes malaria). Some microbes cause disease and others exist in the body without causing harm and may actually be beneficial. Microbes are constantly evolving enabling them to efficiently adapt to new environments. Antimicrobial resistance is the ability of microbes to grow in the presence of a chemical (drug) that would normally kill them or limit their growth. Antimicrobial resistance makes it harder to eliminate infections from the body as existing drugs become less effective. As a result, some infectious diseases are now more difficult to treat than they were just a few decades ago. As more microbes become resistant to antimicrobials, the protective value of these medicines is reduced. Overuse and misuse of antimicrobial medicines are among the factors that have contributed to the development of drug-resistant microbes.

Molecular Oncology
Molecular Oncology a topic of discussion for new discoveries, approaches, as well as technical developments, in basic, clinical and discovery-driven translational cancer research. The emphasis is on work that significantly advances our understanding of disease processes leading to human tumour development and/or establishes novel concepts of clear clinical significance in diagnosis, prognosis and prevention strategies for cancer patients.
Topics include, but are not limited to:
Key biological processes such as cell cycle; DNA repair; apoptosis; invasion and metastasis; angiogenesis and lymphangiogenesis; cell signalling and interactive networks; immune response.
Emerging technologies (genomics, proteomics, functional genomics, metabolomics, tissue arrays, imaging), and model systems.
Biomarkers: diagnosis, prognosis, stratification and efficacy.
Cancer genetics, epigenetics, and genomic instability.
Minimal residual disease, pre-malignant lesions.
Cancer micro-environment.
Molecular pathology.
Tumour immunology.

The concept of cancer “etiology” seems inadequate, at least in its classical use in the pathology of infectious, parasitic, nutrition, metabolic diseases. We consider the use of the terms carcinogenesis, cancer inducing factors or carcinogenic factors more adequate for what happens during tumor cell transformation, with the mention that the term carcinogenesis defines the initiation of a tumor, and oncogenesis its maintenance and subsequent evolution. Tumors develop in those tissues in which cellular homeostasis has been disturbed by hyperplastic, dysplastic or regenerative changes. Clinical and experimental data have proved that during the division process the cell is more susceptible to carcinogenic factors than at rest. Human and veterinary oncology can provide such examples: hyperplastic endometrial and mammary processes that are submitted to hormonal fluctuations represent the usual background for the appearance of cancer; bronchial carcinoma in smokers invariably appears against a dysplastic or metaplasic background of the airways; bone cancer usually occurs at a young age, when physiological osteogenesis is active. These examples demonstrate that the oncogenic process is more frequent in tissues with increased cellular activity. .

Pediatric Neurology
The Neuro-Oncology topic is a multidisciplinary, collaborative topic dedicated to understanding and treating brain tumors and neurological problems associated with cancer. In patient care, the neuro-oncology team employs a high-tech, high-touch approach to treating patients, in recognition of the particular needs of those who have cancers involving the neurological system. In research, the scientists supports investigations into the cellular biology of brain cells and brain cancers, the role of imaging and cell markers in early detection of brain cancers, and whole-genome analysis of gliomas and other cancers. The world oncologists also conducts clinical trials aimed at trying to improve outcomes for neuro-oncological disorders. Neuro-oncology is a specialised cancer field focusing on brain and spine (backbone) tumours. To understand brain and/or spine tumours, it is important to know these tumours can affect your central nervous system. The brain and spine are the two main parts of your central nervous system. These two must talk to each other for your body to work. The spine is a long set of bones (vertebrae) that are linked together from the base of your brain down to your lower back (tailbone). It is also made up of muscle, tissue and ligaments. Inside this linked set of bones, there is also a spinal cord. .

A neoplasm is an abnormal growth of cells, also known as a tumor. Neoplastic diseases are conditions that cause tumor growth — both benign and malignant. Benign tumors are noncancerous growths. They usually grow slowly and can’t spread to other tissues. Malignant tumors are cancerous and can grow slowly or quickly. Malignant tumors carry the risk of metastasis, or spreading to multiple tissues and organs. Exact causes of tumor growth are still being researched. In general, cancerous tumor growth is triggered by DNA mutations within your cells. Your DNA contains genes that tell cells how to operate, grow, and divide. When the DNA changes within your cells, they don’t function properly. This disconnection is what causes cells to become cancerous. There are a number of contributing factors that can cause your genes to mutate and result in benign or malignant tumor growth. Some common factors include:
genetics | age | hormones | smoking| drinking|obesity | sun overexposure | immune disorders | viruses |overexposure to radiation| chemical toxin.

Cancer Cytopathology

The topic of Cancer Cytopathology is to provide a information for the exchange of information among cytopathologists and related oncologic disciplines concerned with the etiology and course of human cancer and its diagnosis and prevention.
Gynecologic Cytopathology | Non-Gynecologic Cytopathology | Fine-Needle Aspiration | Immunocytochemistry | Molecular Diagnostics and Cytogenetics
| Analytical and Quantitative Cytopathology.

Radiation Oncology and Therapy
Radiation oncology is a medical speciality that involves the controlled use of radiation to treat cancer either for cure, or to reduce pain and other symptoms caused by cancer. Radiation therapy (also called radiotherapy) is the term used to describe the actual treatment delivered by the radiation oncology team. Three unique specialist professions are involved in the practice of radiation oncology: Radiation Oncologists(doctors), Radiation Therapists and Radiation Oncology Medical Physicists. These highly trained medical professionals use advanced technologies to deliver safe and effective radiation therapy to cancer patients with as few side effects as possible. Radiation therapy is a part of treatment in around 40% of all patients cured of cancer.
Radiation therapy can be applied safely to a wide range of cancers, and may be used alone or in conjunction with surgery, chemotherapy and other treatments. It is usually completely non-invasive, and accessed through out-patient clinics. Radiation therapy is a highly cost effective cancer treatment. It costs less than 9 cents out of each health-care dollar spent on treating cancer overall, yet it is vital in about 40% of all cancers that are cured. With cancer being the leading cause of death world-wide, investment in improving radiation oncology treatments, helping cancer patients access radiation therapy and building new treatment centres have never been more important. The technology used in radiation oncology is constantly improving. Recent advances have benefited many patients with cancer, resulting in higher cure rates, fewer side effects, shorter treatments and improved quality of life. New technology provides three-dimensional images of tumours that precisely target radiation beams to the cancer, limiting damage to important adjacent organs. Real-time imaging is in development which will enable treatment teams to compensate for tiny involuntary patient movements, such as breathing. .

Stem-Cell Therapy
Stem cells are the body’s raw materials — cells from which all other cells with specialized functions are generated. Under the right conditions in the body or a laboratory, stem cells divide to form more cells called daughter cells.
These daughter cells either become new stem cells (self-renewal) or become specialized cells (differentiation) with a more specific function, such as blood cells, brain cells, heart muscle cells or bone cells. No other cell in the body has the natural ability to generate new cell types. Increase understanding of how diseases occur. By watching stem cells mature into cells in bones, heart muscle, nerves, and other organs and tissue, researchers and doctors may better understand how diseases and conditions develop. Generate healthy cells to replace diseased cells (regenerative medicine). Stem cells can be guided into becoming specific cells that can be used to regenerate and repair diseased or damaged tissues in people. People who might benefit from stem cell therapies include those with spinal cord injuries, type 1 diabetes, Parkinson’s disease, amyotrophic lateral sclerosis, Alzheimer’s disease, heart disease, stroke, burns, cancer and osteoarthritis. Stem cells may have the potential to be grown to become new tissue for use in transplant and regenerative medicine. Researchers continue to advance the knowledge on stem cells and their applications in transplant and regenerative medicine. Embryonic stem cells. These stem cells come from embryos that are three to five days old. At this stage, an embryo is called a blastocyst and has about 150 cells. These are pluripotent (ploo-RIP-uh-tunt) stem cells, meaning they can divide into more stem cells or can become any type of cell in the body. This versatility allows embryonic stem cells to be used to regenerate or repair diseased tissue and organs. Adult stem cells. These stem cells are found in small numbers in most adult tissues, such as bone marrow or fat. Compared with embryonic stem cells, adult stem cells have a more limited ability to give rise to various cells of the body. Until recently, researchers thought adult stem cells could create only similar types of cells. For instance, researchers thought that stem cells residing in the bone marrow could give rise only to blood cells. However, emerging evidence suggests that adult stem cells may be able to create various types of cells. For instance, bone marrow stem cells may be able to create bone or heart muscle cells. This research has led to early-stage clinical trials to test usefulness and safety in people. For example, adult stem cells are currently being tested in people with neurological or heart disease. .

Call for Abstracts

International Conference on Cancer biology and Anti-Cancer Therapies ICCB 2019 Summit invites abstracts of current research in the fields of Cancer Biology, Biologics, Cancer Research, Oncology, Leukaemia, Breast cancer, Bone-Cancer, Anti-Cancer Therapy & its related aspects. Registrants are invited to submit an abstract of their original research for consideration for oral or poster presentation presentations. In general, we encourage more specific to the current research fields representing innovation and recent technologies related to cancer. All the abstracts we receive from aspirants will be reviewed by the Expert Scientific Committee and categorized as speaker talks of either oral or Poster presentations.

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